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Colorectal cancer (CRC) is the leading cause of cancer death; however, targets with broad anti-CRC effects are limited. Sirtuin6 (SIRT6) is a conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that is widely pathologically downregulated in CRC.
MDL-811, an allosteric SIRT6 activator, enhances SIRT6 deacetylation.Pharmacokinetic studies were performed by Medicilon, following standard protocols.
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