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设计、合成和评估具有体内抗炎活性的RIPK1抑制剂,PK研究通过美迪西进行

2023-07-05
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RIPK1 plays a key role in the necroptosis pathway that regulates inflammatory signaling and cell death in various diseases, including inflammatory and neurodegenerative diseases. Herein, researchers report a series of potent RIPK1 inhibitors, represented by compound 70. Compound 70 possesses favorable pharmacokinetic parameters with moderate clearance and good oral bioavailability in SD rat. 

The pharmacokinetic parameters were determined at Medicilon using male SD rats (3 rats per group, 4 groups).

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