美迪西请作答为您介绍GLP-1 的作用逻辑。

GLP-1配合GLP-1R(1)后，GLP-1R在胰岛β癌细胞膜中偶联Gas蛋清，启用卡腺苷环化酶（AC），导致cAMP在癌细胞膜内硫含量提升，可启用卡蛋清激酶A(PKA)和cAMP设定的鸟嘌呤核苷酸对调成分2（Epac-2）。After activation by full agonists such as GLP-1,GLP-1R(1)  couples with Gas activates adenolate cyclase(AC),and causes the accumulation of cAMP.With increasing cAMP levels, protein kinase A（PKA） and the exchange protein directly activated by cAMP-2(Epac-2) are also activated.PKA 和 Epac-2 能能闭合ATP根据的钾铁铁化合物清算检修通道，使体细胞质去极化；还能能激发线电压根据的钙铁铁化合物清算检修通道（VDCC）使钙铁铁化合物内流并行成舞蹈动作电位差，那些渠道结果都将敏感血糖根据性胰岛素的代谢。PKA and Epac-2  trigger the closure of KATP and KV channels,which depolarizes the cell membrane opens voltage-dependent Calcium channels(VDCC) and causes Calcium influx and the promotion of insulin secretion by the islet beta cells

美迪西“GLP-1”新药研发服务平台

美迪西内分泌及代谢性疾病模型