KRAS4g信号的激发也是个多流程的整个过程，必须要 合理的KRAS当地翻译后装饰，体细胞质追踪定位与反应核蛋白的能够 角色。The activation of KRAS signaling is a multi-step process that requires proper KRAS post-translation，plasma membrane-localization and interaction with effector proteins.在細胞外促使的功效下，从灭活的RAS-GDP到成功更改密码的RAS-GDP的转换进一大步促进会了多信息环路的成功更改密码，属于MAPK环路、PI3k 环路和Ral-GEFs环路，在其中以MAPK环路的特征描述更是特别。In response to extracellular stimuli, the conversion from inactive RAS-GDP to active RAS-GDP further promotes the activation of various signaling pathways, which includes MAPK pathway，PI3k pathway and the Ral-GEFs pathway,among them the MAPK pathway is the best characterized.RAS-GDP单独与RAF蛋白酶联系，将RAF激酶宗族从上皮生殖细胞质招纳到膜上，在上皮生殖细胞结构上二聚化并产甲烷。刺激的RAF后来对其上下游底物，即MEK and ERk进行一编磷酸性反馈反馈，并传递滋生移动信号。RAS-GDP directly binds to RAF protein,recruiting RAF Kinese family from cytoplasm to membranes，where they dimerize and become active. The activated RAF subsequently carries out a chain of phospholation reactions to its downstream substrates, MEK and ERk, and propagates the growth signal.
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